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Article

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay.

eNeuro - 1 Jan 2018

Baldo Barbara, Sajjad Muhammad Umar, Cheong Rachel Y, Bigarreau Julie, Vijayvargia Ravi, McLean Catriona, Perrier Anselme L, Seong Ihn Sik, Halliday Glenda, Petersén Åsa, Kirik Deniz

Abstract excerpt

The neurodegenerative Huntington's disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are directed to develop and optimize HTT-lowering methods to improve HD phenotypes. To validate these approaches, there is an immediate need for reliable, sensitive, and easily accessible methods to...

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Identifiers

PMID: 30310861
DOI: 10.1523/ENEURO.0234-18.2018
PMCID: PMC6179573

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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