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Article

Quantification of huntingtin protein species in Huntington's disease patient leukocytes using optimised electrochemiluminescence immunoassays.

PloS one - 1 Jan 2017

Hensman Moss Davina J, Robertson Nicola, Farmer Ruth, Scahill Rachael I, Haider Salman, Tessari Michela A, Flynn Geraldine, Fischer David F, Wild Edward J, Macdonald Douglas, Tabrizi Sarah J

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative condition caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Optimizing peripheral quantification of huntingtin throughout the course of HD is valuable not only to illuminate the natural history and pathogenesis of disease, but also to detect peripheral effects of drugs in clinical trial. RATIONALE: We previously...

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Identifiers

PMID: 29272284
DOI: 10.1371/journal.pone.0189891
PMCID: PMC5741241

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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