Article
Mutational Signatures and Clonal Hematopoiesis in Intestinal Metaplasia across Countries with Varying Stomach Cancer Incidence.
Cancer discovery - 2 Mar 2026
Huang Kie Kyon, Hagihara Takeshi, Lian Benedict Shi Xiang, Ong Zhi Xuan, Lim Shen Kiat, Chong Roxanne Hui Heng, Srivastava Supriya, Kang Jason Xing, Lee May Yin, Tan Angie Lay-Keng, Lee Minghui, Ho Shamaine Wei Ting, Binte Abdul Ghani Siti Aishah, Ng Clara Shi Ya, Liang Ruanyi, Liu Lin, Tay Su Ting, Ong Xuewen, Zhu Feng, Chen Hui, Li Zhen, Ang Tiing Leong, Gotoda Takuji, Huang Robert J, Khor Christopher J L, Kim Hyun-Soo, Lau Louis Ho Shing, Lee Yi-Chia, Takasu Ayaka, Teh Ming, Thian Mann Yie, Tam Wai Leong, Lu Xin, Wong Sunny H, So Jimmy B Y, Chung Hyunsoo, Lee Jonathan, Yeoh Khay Guan, Tan Patrick
Abstract excerpt
Intestinal metaplasia (IM) is a premalignant condition associated with increased risk of gastric cancer-a deadly malignancy with varying geographic incidence. High-depth targeted sequencing of more than 1,500 IM samples from six countries identified 47 significantly mutated genes, including driver genes associated with high-risk populations and worse prognosis (ARID1A), KRAS/MAPK signaling (KRAS, BRAF, MAP2K1,...
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