Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy.

NeuroImage. Clinical - 1 Jan 2021

Bertoglio Daniele, Amhaoul Halima, Goossens Joery, Ali Idrish, Jonckers Elisabeth, Bijnens Tom, Siano Matteo, Wyffels Leonie, Verhaeghe Jeroen, Van der Linden Annemie, Staelens Steven, Dedeurwaerdere Stefanie

Abstract excerpt

Neuroinflammation is a key component of epileptogenesis, the process leading to acquired epilepsy. In recent years, with the development of non-invasive in vivo positron emission tomography (PET) imaging of translocator protein 18 kDa (TSPO), a marker of neuroinflammation, it has become possible to perform longitudinal studies to characterize neuroinflammation at different disease stages in animal models of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epilepsy, Temporal Lobe

Share to Molecular Imaging

Share to Positron-Emission Tomography

Share to Receptors, GABA-A

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 34090124
DOI: 10.1016/j.nicl.2021.102701
PMCID: PMC8182303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy.PMID 34090124Read ↗

[18F]DPA-714 PET Imaging for the Quantitative Evaluation of Early Spatiotemporal Changes of Neuroinflammation in Rat Brain Following Status EpilepticusSemantic proximity Read ↗

Longitudinal in vivo PET imaging of P2X7R and TSPO neuroinflammation markers and myelin load in the TgF344-AD rat model of Alzheimer’s diseaseSemantic proximity Read ↗

Radiolabelled Molecules for Imaging the Translocator Protein (18 kDa) Using Positron Emission TomographySemantic proximity Read ↗

TSPO contributes to neuropathology and cognitive deficits in Alzheimer’s diseaseSemantic proximity Read ↗

Neuroinflammation and metabolic dysfunction in POLG-related mitochondrial epilepsySemantic proximity Read ↗

Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate.Semantic proximity Read ↗

<i>In Vivo</i>Detection of Age- and Disease-Related Increases in Neuroinflammation by<sup>18</sup>F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic MiceSemantic proximity Read ↗

Minute- and second-scale hippocampal network dysfunctions in the 3xTgAD mouse model of Alzheimer’s disease are prevented by TSPO knockoutSemantic proximity Read ↗

Impaired microglial phagocytosis promotes seizure developmentSemantic proximity Read ↗

Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations.Semantic proximity Read ↗

Neuroinflammation: A Signature or a Cause of Epilepsy?Semantic proximity Read ↗

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.