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Neuroinflammation and metabolic dysfunction in POLG-related mitochondrial epilepsy

2026-08-14

Abstract excerpt

Super-refractory status epilepticus is a common neurological manifestation of mitochondrial disease caused by bi-allelic pathogenic variants in POLG. Epilepsy in POLG-related disease typically presents with an explosive onset of status epilepticus, often from an occipital focus, and is associated with extensive neurodegeneration. The neuropathological mechanisms underlying POLG-related mitochondrial epilepsy remai...

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Literature Corpus work
d782f569-a594-52f3-8ce8-7355a25bcd9f
DOI
10.64898/2026.08.12.744403
Open publication

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Neuroinflammation and metabolic dysfunction in POLG-related mitochondrial epilepsyDOI 10.64898/2026.08.12.744403
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