Article
Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network.
Genetic epidemiology - 1 Jul 2015
Hall Molly A, Verma Shefali S, Wallace John, Lucas Anastasia, Berg Richard L, Connolly John, Crawford Dana C, Crosslin David R, de Andrade Mariza, Doheny Kimberly F, Haines Jonathan L, Harley John B, Jarvik Gail P, Kitchner Terrie, Kuivaniemi Helena, Larson Eric B, Carrell David S, Tromp Gerard, Vrabec Tamara R, Pendergrass Sarah A, McCarty Catherine A, Ritchie Marylyn D
Abstract excerpt
Bioinformatics approaches to examine gene-gene models provide a means to discover interactions between multiple genes that underlie complex disease. Extensive computational demands and adjusting for multiple testing make uncovering genetic interactions a challenge. Here, we address these issues using our knowledge-driven filtering method, Biofilter, to identify putative single nucleotide polymorphism (SNP)...
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