Article
Gene-level association analysis of ordinal traits with functional ordinal logistic regressions.
Genetic epidemiology - 1 Jul 2022
Chiu Chi-Yang, Wang Shuqi, Zhang Bingsong, Luo Yutong, Simpson Claire, Zhang Wei, Wilson Alexander F, Bailey-Wilson Joan E, Agron Elvira, Chew Emily Y, Zhang Jun, Xiong Momiao, Fan Ruzong
Abstract excerpt
In this paper, we develop functional ordinal logistic regression (FOLR) models to perform gene-based analysis of ordinal traits. In the proposed FOLR models, genetic variant data are viewed as stochastic functions of physical positions and the genetic effects are treated as a function of physical positions. The FOLR models are built upon functional data analysis which can be revised to analyze the ordinal traits...
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