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Article

APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.

PLoS genetics - 1 Aug 2015

Tkatchenko Andrei V, Tkatchenko Tatiana V, Guggenheim Jeremy A, Verhoeven Virginie J M, Hysi Pirro G, Wojciechowski Robert, Singh Pawan Kumar, Kumar Ashok, Thinakaran Gopal, Williams Cathy

Abstract excerpt

Myopia is the most common vision disorder and the leading cause of visual impairment worldwide. However, gene variants identified to date explain less than 10% of the variance in refractive error, leaving the majority of heritability unexplained ("missing heritability"). Previously, we reported t...

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Identifiers

PMID: 26313004
DOI: 10.1371/journal.pgen.1005432
PMCID: PMC4551475

Genes

APLP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26313004-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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