Article
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.
Nature communications - 31 Mar 2015
Miyake Masahiro, Yamashiro Kenji, Tabara Yasuharu, Suda Kenji, Morooka Satoshi, Nakanishi Hideo, Khor Chiea-Chuen, Chen Peng, Qiao Fan, Nakata Isao, Akagi-Kurashige Yumiko, Gotoh Norimoto, Tsujikawa Akitaka, Meguro Akira, Kusuhara Sentaro, Polasek Ozen, Hayward Caroline, Wright Alan F, Campbell Harry, Richardson Andrea J, Schache Maria, Takeuchi Masaki, Mackey David A, Hewitt Alex W, Cuellar Gabriel, Shi Yi, Huang Luling, Yang Zhenglin, Leung Kim Hung, Kao Patrick Y P, Yap Maurice K H, Yip Shea Ping, Moriyama Muka, Ohno-Matsui Kyoko, Mizuki Nobuhisa, MacGregor Stuart, Vitart Veronique, Aung Tin, Saw Seang-Mei, Tai E-Shyong, Wong Tien Yin, Cheng Ching-Yu, Baird Paul N, Yamada Ryo, Matsuda Fumihiko, Yoshimura Nagahisa
Abstract excerpt
Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and...
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