Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles.

Molecular biology of the cell - 1 Feb 2008

Cammarato Anthony, Dambacher Corey M, Knowles Aileen F, Kronert William A, Bodmer Rolf, Ocorr Karen, Bernstein Sanford I

Abstract excerpt

Striated muscle myosin is a multidomain ATP-dependent molecular motor. Alterations to various domains affect the chemomechanical properties of the motor, and they are associated with skeletal and cardiac myopathies. The myosin transducer domain is located near the nucleotide-binding site. Here, we helped define the role of the transducer by using an integrative approach to study how Drosophila melanogaster...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomechanical Phenomena
Share to Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Mutant Proteins

Share to Myocardium

Share to Myofibrils

Share to Myosins

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 18045988
DOI: 10.1091/mbc.e07-09-0890
PMCID: PMC2230588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles.PMID 18045988Read ↗

Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.Semantic proximity Read ↗

Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities.Semantic proximity Read ↗

Novel model of distal myopathy caused by the myosin rod mutation R1500P disrupts acto-myosin bindingSemantic proximity Read ↗

Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor.Semantic proximity Read ↗

Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor functionSemantic proximity Read ↗

Mutations in the catalytic domain of human β-cardiac myosin that cause early onset hypertrophic cardiomyopathy significantly increase the fundamental parameters that determine ensemble force and velocitySemantic proximity Read ↗

A Titin Knock-in model for Hereditary Myopathy with Early Respiratory FailureSemantic proximity Read ↗

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respirationSemantic proximity Read ↗

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor functionSemantic proximity Read ↗

The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin.Semantic proximity Read ↗

Dominant myosin storage myopathy mutations disrupt striated muscles in Drosophila and the myosin tail-tail interactome of human cardiac thick filaments.Semantic proximity Read ↗

Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.