Article
Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy.
Journal of the American College of Cardiology - 26 Jan 2010
Lakdawala Neal K, Dellefave Lisa, Redwood Charles S, Sparks Elizabeth, Cirino Allison L, Depalma Steve, Colan Steven D, Funke Birgit, Zimmerman Rebekah S, Robinson Paul, Watkins Hugh, Seidman Christine E, Seidman J G, McNally Elizabeth M, Ho Carolyn Y
Abstract excerpt
OBJECTIVES: We sought to further define the role of sarcomere mutations in dilated cardiomyopathy (DCM) and associated clinical phenotypes. BACKGROUND: Mutations in several contractile proteins contribute to DCM, but definitive evidence for the roles of most sarcomere genes remains limited by the lack of robust genetic support. METHODS: Direct sequencing of 6 sarcomere genes was performed on 334 probands with...
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