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Article

Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities.

The Journal of biological chemistry - 12 Aug 2011

Bloemink Marieke J, Melkani Girish C, Dambacher Corey M, Bernstein Sanford I, Geeves Michael A

Abstract excerpt

Two Drosophila myosin II point mutations (D45 and Mhc(5)) generate Drosophila cardiac phenotypes that are similar to dilated or restrictive human cardiomyopathies. Our homology models suggest that the mutations (A261T in D45, G200D in Mhc(5)) could stabilize (D45) or destabilize (Mhc(5)) loop 1 of myosin, a region known to influence ADP release. To gain insight into the molecular mechanism that causes the...

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Identifiers

PMID: 21680742
DOI: 10.1074/jbc.M111.258228
PMCID: PMC3151086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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