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Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function

18 Sept 2006

Abstract excerpt

Dilated cardiomyopathy (DCM) leads to heart failure, a leading cause of death in industrialized nations. Approximately 30% of DCM cases are genetic in origin, with some resulting from point mutations in cardiac myosin, the molecular motor of the heart. The effects of these mutations on myosin's molecular mechanics have not been determined. We have engineered two murine models characterizing the physiological,...

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PMID: 16983074
DOI: 10.1073/pnas.0606383103

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