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A carrier-free multiplexed gene editing system applicable for suspension cells

25 Jun 2019

Abstract excerpt

Genetically engineered cells via CRISPR/Cas9 system can serve as powerful sources for cancer immunotherapeutic applications. Furthermore, multiple genetic alterations are necessary to overcome tumor-induced immune-suppressive mechanisms. However, one of the major obstacles is the technical difficulty with efficient multiple gene manipulation of suspension cells due to the low transfection efficacy. Herein, we...

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PMID: 31280073
DOI: 10.1016/j.biomaterials.2019.119298

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