Mapping of HIV-1C Transmission Networks Reveals Extensive Spread of Viral Lineages Across Villages in Botswana Treatment-as-Prevention Trial.

doi:10.1093/infdis/jiaa276

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Article

Mapping of HIV-1C Transmission Networks Reveals Extensive Spread of Viral Lineages Across Villages in Botswana Treatment-as-Prevention Trial.

The Journal of infectious diseases - 15 Nov 2020

Novitsky Vlad, Zahralban-Steele Melissa, Moyo Sikhulile, Nkhisang Tapiwa, Maruapula Dorcas, McLane Mary Fran, Leidner Jean, Bennett Kara, Wirth Kathleen E, Gaolathe Tendani, Kadima Etienne, Chakalisa Unoda, Pretorius Holme Molly, Lockman Shahin, Mmalane Mompati, Makhema Joseph, Gaseitsiwe Simani, DeGruttola Victor, Essex M

Abstract excerpt

BACKGROUND: Phylogenetic mapping of HIV-1 lineages circulating across defined geographical locations is promising for better understanding HIV transmission networks to design optimal prevention interventions. METHODS: We obtained near full-length HIV-1 genome sequences from people living with HIV (PLWH), including participants on antiretroviral treatment in the Botswana Combination Prevention Project, conducted...

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PMID: 32492145
DOI: 10.1093/infdis/jiaa276
PMCID: PMC7936922

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