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Gastrointestinal jumbo phages possess independent synthesis and utilization systems of NAD+

20 Dec 2024

Abstract excerpt

Jumbo phages, phages with genomes > 200 kbp, contain some unique genes for successful reproduction in their bacterial hosts. Due to complex and massive genomes analogous to those of small-celled bacteria, how jumbo phages complete their life cycle remains largely undefined. In this study, we assembled 668 high-quality jumbo phage genomes from over 15 terabytes (TB) of intestinal metagenomic data from 955 samples...

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PMID: 39707494
DOI: 10.1186/s40168-024-01984-w

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