Article
Bacteriophage T5 dUTPase: Combination of Common Enzymatic and Novel Functions.
International journal of molecular sciences - 10 Jan 2024
Glukhov Anatoly, Marchenkov Victor, Dzhus Ulyana, Krutilina Antonina, Selikhanov Georgii, Gabdulkhakov Azat
Abstract excerpt
The main function of dUTPases is to regulate the cellular levels of dUTP and dTTP, thereby playing a crucial role in DNA repair mechanisms. Despite the fact that mutant organisms with obliterated dUTPase enzymatic activity remain viable, it is not possible to completely knock out the dut gene due to the lethal consequences of such a mutation for the organism. As a result, it is considered that this class of...
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