Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation.

doi:10.1186/s13059-021-02375-2

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Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation.

Genome biology - 1 Jun 2021

Padmanabhan Nisha, Kyon Huang Kie, Boot Arnoud, Lim Kevin, Srivastava Supriya, Chen Shuwen, Wu Zhiyuan, Lee Hyung-Ok, Mukundan Vineeth T, Chan Charlene, Chan Yarn Kit, Xuewen Ong, Pitt Jason J, Isa Zul Fazreen Adam, Xing Manjie, Lee Ming Hui, Tan Angie Lay Keng, Ting Shamaine Ho Wei, Luftig Micah A, Kappei Dennis, Kruger Warren D, Bian Jinsong, Ho Ying Swan, Teh Ming, Rozen Steve George, Tan Patrick

Abstract excerpt

BACKGROUND: CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype, observed in multiple malignancies and associated with the epigenetic silencing of tumor suppressors. Currently, for most cancers including gastric cancer (GC), mechanisms underlying CIMP remain poorly understood. We sought to discover molecular contributors to CIMP in GC, by performing global DNA methylation, gene expression,...

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PMID: 34074348
DOI: 10.1186/s13059-021-02375-2
PMCID: PMC8170989

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