Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations.

doi:10.1007/s10120-021-01191-8

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Article

Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Sept 2021

Nikaido Mitsuhiro, Kakiuchi Nobuyuki, Miyamoto Shin'ichi, Hirano Tomonori, Takeuchi Yasuhide, Funakoshi Taro, Yokoyama Akira, Ogasawara Tatsuki, Yamamoto Yoshihiro, Yamada Atsushi, Setoyama Takeshi, Shimizu Takahiro, Kato Yukari, Uose Suguru, Sakurai Takaki, Minamiguchi Sachiko, Obama Kazutaka, Sakai Yoshiharu, Muto Manabu, Chiba Tsutomu, Ogawa Seishi, Seno Hiroshi

Abstract excerpt

BACKGROUND: In Helicobacter pylori (Hp)-uninfected individuals, diffuse-type gastric cancer (DGC) was reported as the most common type of cancer. However, the carcinogenic mechanism of Hp-uninfected sporadic DGC is largely unknown. METHODS: We performed whole-exome sequencing of Hp-uninfected DGCs and Hp-uninfected normal gastric mucosa. For advanced DGCs, external datasets were also analyzed. RESULTS: Eighteen...

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PMID: 33961152
DOI: 10.1007/s10120-021-01191-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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