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Article

Frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer.

PloS one - 1 Jan 2012

Zhao Hong, Li Qinshan, Wang Jian, Su Xianwei, Ng Ka Man, Qiu Tian, Shan Ling, Ling Yun, Wang Linfang, Cai Jianqiang, Ying Jianming

Abstract excerpt

BACKGROUND: Both gastric and colorectal cancers (CRC) are the most frequently occurring malignancies worldwide with the overall survival of these patients remains unsatisfied. Identification of tumor suppressor genes (TSG) silenced by promoter CpG methylation uncovers mechanisms of tumorigenesis and identifies new epigenetic biomarkers for early cancer detection and prognosis assessment....

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Source

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Identifiers

PMID: 23152928
DOI: 10.1371/journal.pone.0049683
PMCID: PMC3496708

Genes

CBS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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