Article

Causal effect of negative emotions and insomnia on sepsis and its associated clinical indicators: A Mendelian randomisation and mediation analysis

2023-09-18

Abstract excerpt

<h4>Background: </h4> Negative emotions and insomnia (NEI) are associated with changes in inflammatory factors, which play a role in sepsis. Methods We performed Mendelian randomisation (MR) analysis of genome-wide association study (GWAS) data of NEI and sepsis to investigate the causal effect of NEI on sepsis. We employed linkage disequilibrium score regression (LDSC) to calculate the genetic correlation betwee...

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Literature Corpus work: 7da45bd8-d6ec-56d5-990c-4f5fd0732635
DOI: 10.21203/rs.3.rs-3286487/v1

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