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Article

Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.

PLoS biology - 1 Jun 2021

Sueiro-Olivares Monica, Scott Jennifer, Gago Sara, Petrovic Dunja, Kouroussis Emilia, Zivanovic Jasmina, Yu Yidong, Strobel Marlene, Cunha Cristina, Thomson Darren, Fortune-Grant Rachael, Thusek Sina, Bowyer Paul, Beilhack Andreas, Carvalho Agostinho, Bignell Elaine, Filipovic Milos R, Amich Jorge

Abstract excerpt

Aspergillus fumigatus is a human fungal pathogen that can cause devastating pulmonary infections, termed "aspergilloses," in individuals suffering immune imbalances or underlying lung conditions. As rapid adaptation to stress is crucial for the outcome of the host-pathogen interplay, here we investigated the role of the versatile posttranslational modification (PTM) persulfidation for both fungal virulence and...

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Identifiers

PMID: 34061822
DOI: 10.1371/journal.pbio.3001247
PMCID: PMC8168846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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