Article

Convergent evolution of a fungal effector enabling phagosome membrane penetration

2025-03-06

Abstract excerpt

<h4>Summary</h4> The ability of pathogens to evade phagosomal killing is critical for their pathogenicity. Previously, we had identified the HscA effector protein in the clinically important fungal pathogen Aspergillus fumigatus , which redirects conidia-containing phagosomes from the degradative to the non-degradative pathway. Here, we discovered a pathogenic form of this surface protein, determined by a single...

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Literature Corpus work: 7cfa5261-2cec-5eb0-a0f4-7e8d85f10bc3
DOI: 10.1101/2025.03.06.641871

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