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The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen

1 Apr 2020

Abstract excerpt

Identification of multiple histone acylations diversifies transcriptional control by metabolism, but their functions are incompletely defined. Here we report evidence of histone crotonylation in the human fungal pathogen Candida albicans. We define the enzymes that regulate crotonylation and show its dynamic control by environmental signals: carbon sources, the short-chain fatty acids butyrate and crotonate, and...

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PMID: 32320659
DOI: 10.1016/j.celrep.2020.107528

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