Article
A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.
PLoS pathogens - 1 May 2015
Santiago-Tirado Felipe H, Peng Tao, Yang Meng, Hang Howard C, Doering Tamara L
Abstract excerpt
Cryptococcus neoformans is an opportunistic yeast that kills over 625,000 people yearly through lethal meningitis. Host phagocytes serve as the first line of defense against this pathogen, but fungal engulfment and subsequent intracellular proliferation also correlate with poor patient outcome. Defining the interactions of this facultative intracellular pathogen with host phagocytes is key to understanding the...
Topics
- Acylation
- Acyltransferases
- Cell Adhesion
- Cell Line
- Cell Wall
- Cryptococcosis
- Cryptococcus neoformans
- Fungal Proteins
- Gene Deletion
- Host-Pathogen Interactions
- Humans