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Article

Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen

8 Aug 2011

Abstract excerpt

In a restricted group of opportunistic fungal pathogens the universal leucine CUG codon is translated both as serine (97%) and leucine (3%), challenging the concept that translational ambiguity has a negative impact in living organisms. To elucidate the molecular mechanisms underlying the in vivo tolerance to a nonconserved genetic code alteration, we have undertaken an extensive structural analysis of proteins...

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PMID: 21825144
DOI: 10.1073/pnas.1102835108

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