The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.

doi:10.1007/s10565-021-09617-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.

Cell biology and toxicology - 1 Oct 2022

Yakhine-Diop Sokhna M S, Rodríguez-Arribas Mario, Canales-Cortés Saray, Martínez-Chacón Guadalupe, Uribe-Carretero Elisabet, Blanco-Benítez Mercedes, Duque-González Gema, Paredes-Barquero Marta, Alegre-Cortés Eva, Climent Vicente, Aiastui Ana, López de Munain Adolfo, Bravo-San Pedro José M, Niso-Santano Mireia, Fuentes José M, González-Polo Rosa A

Abstract excerpt

Autophagy is a mechanism responsible for the degradation of cellular components to maintain their homeostasis. However, autophagy is commonly altered and compromised in several diseases, including neurodegenerative disorders. Parkinson's disease (PD) can be considered a multifactorial disease because environmental factors, genetic factors, and aging are involved. Several genes are involved in PD pathology, among...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mitophagy

Share to Mutation

Share to Parkinson Disease

Share to Parkinson's Disease Mechanisms and Treatments

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 34060004
DOI: 10.1007/s10565-021-09617-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.PMID 34060004Read ↗

Parkinson's disease and mitophagy: an emerging role for LRRK2.Semantic proximity Read ↗

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's DiseaseSemantic proximity Read ↗

Dysregulation of autophagy and mitochondrial function in Parkinson’s diseaseSemantic proximity Read ↗

LRRK2 at the Crossroad of Aging and Parkinson's Disease.Semantic proximity Read ↗

The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.Semantic proximity Read ↗

Role of Autophagy Pathway in Parkinson’s Disease and Related Genetic Neurological DisordersSemantic proximity Read ↗

Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s DiseaseSemantic proximity Read ↗

Role of Autophagy in Parkinson's Disease.Semantic proximity Read ↗

LRRK2-mediated mitochondrial dysfunction in Parkinson's disease.Semantic proximity Read ↗

Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson's Disease.Semantic proximity Read ↗

Pathological and Therapeutic Advances in Parkinson’s Disease: Mitochondria in the InterplaySemantic proximity Read ↗

LRRK2 and Proteostasis in Parkinson's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.