Article
Role of Autophagy Pathway in Parkinson’s Disease and Related Genetic Neurological Disorders
12 May 2023
Abstract excerpt
The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in the elimination of damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding of the mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview of the general importance of autophagy in Parkinson's disease and related disorders of the central nervous system....
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