Article
The DNA methylome of human peripheral blood mononuclear cells.
PLoS biology - 9 Nov 2010
Li Yingrui, Zhu Jingde, Tian Geng, Li Ning, Li Qibin, Ye Mingzhi, Zheng Hancheng, Yu Jian, Wu Honglong, Sun Jihua, Zhang Hongyu, Chen Quan, Luo Ruibang, Chen Minfeng, He Yinghua, Jin Xin, Zhang Qinghui, Yu Chang, Zhou Guangyu, Sun Jinfeng, Huang Yebo, Zheng Huisong, Cao Hongzhi, Zhou Xiaoyu, Guo Shicheng, Hu Xueda, Li Xin, Kristiansen Karsten, Bolund Lars, Xu Jiujin, Wang Wen, Yang Huanming, Wang Jian, Li Ruiqiang, Beck Stephan, Wang Jun, Zhang Xiuqing
Abstract excerpt
DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells. Using whole-genome bisulfite sequencing at 24.7-fold coverage (12.3-fold per strand), we report a comprehensive (92.62%) methylome and analysis of the unique sequences in human peripheral blood...
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