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MEA-LINK identifies the CCL4-CCR5 axis in neuronal hyperactivity control by human microglia

2026-02-06

Abstract excerpt

Microglia, the resident immune cells of the brain, act along a spectrum to maintain CNS homeostasis, respond to perturbations, and control neuronal activity. Disentangling the molecular mechanisms of human microglia-neuron crosstalk remains challenging due to the context-dependent, dynamic nature of their interaction. We introduce MEA-LINK, a systems-approach leveraging natural variation to screen for immune modul...

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Literature Corpus work
4d9725e9-3fd8-5a47-9029-c1694f199ed4
DOI
10.64898/2026.02.04.703799
Open publication

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MEA-LINK identifies the CCL4-CCR5 axis in neuronal hyperactivity control by human microgliaDOI 10.64898/2026.02.04.703799
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