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Article

Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function.

Molecular metabolism - 1 Nov 2021

Kuo Taiyi, Du Wen, Miyachi Yasutaka, Dadi Prasanna K, Jacobson David A, Segrè Daniel, Accili Domenico

Abstract excerpt

OBJECTIVE: Genetic and acquired abnormalities contribute to pancreatic β-cell failure in diabetes. Transcription factors Hnf4α (MODY1) and FoxO1 are respective examples of these two components and act through β-cell-specific enhancers. However, their relationship is unclear. METHODS: In this report, we show by genome-wide interrogation of chromatin modifications that ablation of FoxO1 in mature β-cells enriches...

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Share to Epistasis, Genetic
Share to Forkhead Box Protein O1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34048961
DOI: 10.1016/j.molmet.2021.101256
PMCID: PMC8225970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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