Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CTCF driven TERRA transcription facilitates completion of telomere DNA replication.

Nature communications - 13 Dec 2017

Beishline Kate, Vladimirova Olga, Tutton Stephen, Wang Zhuo, Deng Zhong, Lieberman Paul M

Abstract excerpt

Telomere repeat DNA forms a nucleo-protein structure that can obstruct chromosomal DNA replication, especially under conditions of replication stress. Transcription of telomere repeats can initiate at subtelomeric CTCF-binding sites to generate telomere repeat-encoding RNA (TERRA), but the role of transcription, CTCF, and TERRA in telomere replication is not known. Here, we have used CRISPR/Cas9 gene editing to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCCTC-Binding Factor
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA Replication

Share to Gene Editing

Share to HCT116 Cells

Share to Telomere

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 29235471
DOI: 10.1038/s41467-017-02212-w
PMCID: PMC5727389

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CTCF driven TERRA transcription facilitates completion of telomere DNA replication.PMID 29235471Read ↗

The Emerging Roles of TERRA in Telomere Maintenance and Genome StabilitySemantic proximity Read ↗

Telomeric RNAs are essential to maintain telomeres.Semantic proximity Read ↗

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integritySemantic proximity Read ↗

Role of TERRA in the Regulation of Telomere LengthSemantic proximity Read ↗

Regulated expression of the lncRNA TERRA and its impact on telomere biology.Semantic proximity Read ↗

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short TelomeresSemantic proximity Read ↗

Functional characterization of the TERRA transcriptome at damaged telomeresSemantic proximity Read ↗

TERRA long noncoding RNA: At the interphase of telomere damage, rescue and signalingSemantic proximity Read ↗

TERRA and the alternative lengthening of telomeres: a dangerous affairSemantic proximity Read ↗

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.Semantic proximity Read ↗

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome endsSemantic proximity Read ↗

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.