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Article

STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.

Cancer research - 15 Aug 2021

Koenig Michael J, Agana Bernice A, Kaufman Jacob M, Sharpnack Michael F, Wang Walter Z, Weigel Christoph, Navarro Fabio C P, Amann Joseph M, Cacciato Nicole, Arasada Rajeswara Rao, Gerstein Mark B, Wysocki Vicki H, Oakes Christopher, Carbone David P

Abstract excerpt

STK11 (liver kinase B1, LKB1) is the fourth most frequently mutated gene in lung adenocarcinoma, with loss of function observed in up to 30% of all cases. Our previous work identified a 16-gene signature for LKB1 loss of function through mutational and nonmutational mechanisms. In this study, we applied this genetic signature to The Cancer Genome Atlas (TCGA) lung adenocarcinoma samples and discovered a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34045189
DOI: 10.1158/0008-5472.CAN-20-3199
PMCID: PMC8373682

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STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.PMID 34045189Read ↗

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