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Article

LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2014

Kaufman Jacob M, Amann Joseph M, Park Kyungho, Arasada Rajeswara Rao, Li Haotian, Shyr Yu, Carbone David P

Abstract excerpt

INTRODUCTION: Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer, and understanding the pathways and phenotypes altered as a consequence will aid the development of targeted therapeutic strategies. Gene and protein expressions in a murine model of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (Kras)-mutant lung cancer have been studied to gain insight into the biology of...

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Identifiers

PMID: 24828662
DOI: 10.1097/JTO.0000000000000173
PMCID: PMC4026179

Genes

KEAP1
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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