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Article

SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression.

Cell reports - 1 Jun 2021

Nemudryi Artem, Nemudraia Anna, Wiegand Tanner, Nichols Joseph, Snyder Deann T, Hedges Jodi F, Cicha Calvin, Lee Helen, Vanderwood Karl K, Bimczok Diane, Jutila Mark A, Wiedenheft Blake

Abstract excerpt

Over 950,000 whole-genome sequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the world. These sequences are critical for understanding the spread and evolution of SARS-CoV-2. Using global phylogenomics, we show that mutations frequently occur in the C-terminal end of ORF7a. We isolate one of these mutant viruses from a patient sample and...

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Identifiers

PMID: 34043946
DOI: 10.1016/j.celrep.2021.109197
PMCID: PMC8118641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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