Article

Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution

2023-09-23

Abstract excerpt

Knockout of the ORF8 protein has repeatedly spread through the global viral population during SARS-CoV-2 evolution. Here we use both regional and global pathogen sequencing to explore the selection pressures underlying its loss. In Washington State, we identified transmission clusters with ORF8 knockout throughout SARS-CoV-2 evolution, not just on novel, high fitness viral backbones. Indeed, ORF8 is truncated more...

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Literature Corpus work: f89b01c1-974d-57e5-bc43-af7ef9ea5074
DOI: 10.1101/2023.09.21.23295927

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