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Article

Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution

13 Apr 2024

Abstract excerpt

Knockout of the ORF8 protein has repeatedly spread through the global viral population during SARS-CoV-2 evolution. Here we use both regional and global pathogen sequencing to explore the selection pressures underlying its loss. In Washington State, we identified transmission clusters with ORF8 knockout throughout SARS-CoV-2 evolution, not just on novel, high fitness viral backbones. Indeed, ORF8 is truncated...

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PMID: 38615031
DOI: 10.1038/s41467-024-47599-5

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