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Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion

21 Jan 2025

Abstract excerpt

Coronaviruses express their structural and accessory genes via a set of subgenomic RNAs, whose synthesis is directed by transcription regulatory sequences (TRSs) in the 5' genomic leader and upstream of each body open reading frame. In SARS-CoV-2, the TRS has the consensus AAACGAAC; upon searching for emergence of this motif in the global SARS-CoV-2 sequences, we find that it evolves frequently, especially in the...

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PMID: 39836705
DOI: 10.1371/journal.pbio.3002982

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