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Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF

26 May 2021

Abstract excerpt

Tau protein forms self-replicating assemblies (seeds) that may underlie progression of pathology in Alzheimer's disease (AD) and related tauopathies. Seeding in recombinant protein preparations and brain homogenates has been quantified with "biosensor" cell lines that express tau with a disease-associated mutation (P301S) fused to complementary fluorescent proteins. Quantification of induced aggregation in cells...

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PMID: 34039426
DOI: 10.1186/s40478-021-01185-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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