Article
Acute pharmacological degradation of Helios destabilizes regulatory T cells.
Nature chemical biology - 1 Jun 2021
Wang Eric S, Verano Alyssa L, Nowak Radosław P, Yuan J Christine, Donovan Katherine A, Eleuteri Nicholas A, Yue Hong, Ngo Kenneth H, Lizotte Patrick H, Gokhale Prafulla C, Gray Nathanael S, Fischer Eric S
Abstract excerpt
The zinc-finger transcription factor Helios is critical for maintaining the identity, anergic phenotype and suppressive activity of regulatory T (Treg) cells. While it is an attractive target to enhance the efficacy of currently approved immunotherapies, no existing approaches can directly modulate Helios activity or abundance. Here, we report the structure-guided development of small molecules that recruit the...
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