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Macrophage Migration and Phagocytosis Are Controlled by Kindlin-3's Link to the Cytoskeleton

24 Feb 2020

Abstract excerpt

Major myeloid cell functions from adhesion to migration and phagocytosis are mediated by integrin adhesion complexes, also known as adhesome. The presence of a direct integrin binding partner Kindlin-3 is crucial for these functions, and its lack causes severe immunodeficiency in humans. However, how Kindlin-3 is incorporated into the adhesome and how its function is regulated is poorly understood. In this study,...

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PMID: 32094207
DOI: 10.4049/jimmunol.1901134

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