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Article

Clinical and epigenetic features of colorectal cancer patients with somatic POLE proofreading mutations.

Clinical epigenetics - 25 May 2021

Kawai Takashi, Nyuya Akihiro, Mori Yoshiko, Tanaka Takehiro, Tanioka Hiroaki, Yasui Kazuya, Toshima Toshiaki, Taniguchi Fumitaka, Shigeyasu Kunitoshi, Umeda Yuzo, Fujiwara Toshiyoshi, Okawaki Makoto, Yamaguchi Yoshiyuki, Goel Ajay, Nagasaka Takeshi

Abstract excerpt

BACKGROUND: Mutations in the POLE gene result in an ultra-hypermutated phenotype in colorectal cancer (CRC); however, the molecular characterisation of epigenetic alterations remains unclear. We examined the genetic and epigenetic profiles of POLE-mutant CRC to elucidate the clinicopathological features of the associated genetic and epigenetic alterations. RESULTS: Tumour tissues (1,013) obtained from a cohort of...

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Identifiers

PMID: 34034807
DOI: 10.1186/s13148-021-01104-7
PMCID: PMC8146650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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