Article

Pathogenic germline variants in patients with early-onset colorectal cancer according to phenotype.

2024-10-07

Abstract excerpt

<title>Abstract</title> <p>We assessed retrospectively the prevalence of pathogenic germline variants (PGVs) in 271 French adult patients diagnosed with colorectal cancer (CRC) before age 41, stratified by phenotype. <italic>APC, BMPR1A, CDH1, EPCAM, MLH1, MSH2, MSH3, MSH6, MUTYH, POLE, POLD1, PTEN, PMS2, SMAD4,</italic> and <italic>STK11</italic>were analysed. Overall, 21.4% of cases carried a PGV. A high preval...

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Literature Corpus work: 59a1f76a-8921-5b58-bdf8-33e10271839b
DOI: 10.21203/rs.3.rs-5002627/v1

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