Article

Ultra-Hypermutation Driven by POLE Mutation in Metastatic Colorectal Cancer: A Case for Immunotherapy Without dMMR

2024-12-18

Abstract excerpt

<title>Abstract</title> <p>Colorectal cancer (CRC) is among the leading causes of cancer-related mortality globally. Metastatic colorectal cancer (mCRC) with ultra-hypermutation is uncommon and its underlying pathogenesis remains incompletely characterized. Additionally, the response to immunotherapy in ultra-hypermutated mCRC is not well defined. Here we report a unique case of a 33-year-old Chinese woman with r...

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Literature Corpus work: 730ae22d-ab79-5c9b-a9b3-e83ed01564e0
DOI: 10.21203/rs.3.rs-5450020/v1

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