Morphological, immunophenotypical and molecular features of hypermutation in colorectal carcinomas with mutations in DNA polymerase ε ( POLE )

Abstract excerpt

Aims Colorectal carcinomas (CRC) with mismatch repair (MMR) deficiency have increased tumour mutation burden and respond to immune check‐point inhibitor therapy. The Cancer Genome Atlas identified hypermutated CRCs with somatic mutations in DNA polymerase ε ( POLE ) with mutation burdens exceeding that of MMR‐deficient CRCs. Methods and results To identify the morphological, immunophenotypical and molecular...

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