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Article

Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability.

PloS one - 1 Jan 2018

Haruma Tomoko, Nagasaka Takeshi, Nakamura Keiichiro, Haraga Junko, Nyuya Akihiro, Nishida Takeshi, Goel Ajay, Masuyama Hisashi, Hiramatsu Yuji

Abstract excerpt

BACKGROUND: The molecular characterization of endometrial cancer (EC) can facilitate identification of various tumor subtypes. Although EC patients with POLE mutations reproducibly demonstrate better prognosis, the outcome of patients with microsatellite instability (MSI) remains controversial. This study attempted to interrogate whether genetic stratification of EC can identify distinct subsets with prognostic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29659608
DOI: 10.1371/journal.pone.0195655
PMCID: PMC5901772

Genes

POLE
MLH1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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