Polymerase ɛ (<scp><i>POLE</i></scp>) mutations in endometrial cancer: Clinical outcomes and implications for <scp>L</scp>ynch syndrome testing

Abstract excerpt

BACKGROUND: DNA polymerase ɛ (POLE) exonuclease domain mutations characterize a subtype of endometrial cancer (EC) with a markedly increased somatic mutational burden. POLE-mutant tumors were described as a molecular subtype with improved progression-free survival by The Cancer Genome Atlas. In this study, the frequency, spectrum, prognostic significance, and potential clinical application of POLE mutations were...

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