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Article

Functional Mapping of Genetic Interactions between HLA-Cw6 and LCE3A in Psoriasis.

The Journal of investigative dermatology - 1 Nov 2021

Chandra Aditi, Das Shantanab, Mazumder Sayani, Senapati Swapan, Chatterjee Gobinda, Chatterjee Raghunath

Abstract excerpt

Functional studies to delineate the molecular mechanisms of causal genetic variants are the main focus in the post-GWAS era. Previous GWASs have identified >50 susceptibility loci associated with psoriasis. Functional understanding of the biology underlying the disease risk of most of these associated loci is unclear. In this study, we identified a regulatory SNP at the putative enhancer of the LCE3A gene within...

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PMID: 34029573
DOI: 10.1016/j.jid.2021.04.020

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