Article
Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction with PSORS1.
Journal of medical genetics - 1 Nov 2009
Hüffmeier U, Lascorz J, Becker T, Schürmeier-Horst F, Magener A, Ekici A B, Endele S, Thiel C T, Thoma-Uszynski S, Mössner R, Reich K, Kurrat W, Wienker T F, Traupe H, Reis A
Abstract excerpt
BACKGROUND: Psoriasis is a genetically complex, chronic inflammatory skin disease. The authors have previously identified a susceptibility locus on chromosome 19p13 (PSORS6). METHODS AND RESULTS: In a follow-up linkage disequilibrium (LD) study in an independent family based cohort, the authors found evidence for association to a newly discovered microsatellite at this locus (D19SPS21, p<5.3x10(-5)). An LD based...
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