Article
Characterization of the major susceptibility region for psoriasis at chromosome 6p21.3.
The Journal of investigative dermatology - 1 Sept 1999
Balendran N, Clough R L, Arguello J R, Barber R, Veal C, Jones A B, Rosbotham J L, Little A M, Madrigal A, Barker J N, Powis S H, Trembath R C
Abstract excerpt
Psoriasis is a common inflammatory skin condition caused by genetic and environmental factors. Recent genome-wide linkage analyses have identified a locus encoding susceptibility to psoriasis and placed this gene in the 12 cM interval between markers D6S426 and D6S276 on chromosome 6p21.3. This is a broad region and encompasses the human major histocompatibility complex. We have sought to localize the...
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